Article
Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein.
The Journal of biological chemistry - 14 Dec 2012
Terrasse Rémi, Tacnet-Delorme Pascale, Moriscot Christine, Pérard Julien, Schoehn Guy, Vernet Thierry, Thielens Nicole M, Di Guilmi Anne Marie, Frachet Philippe
Abstract excerpt
C1q, a key component of the classical complement pathway, is a major player in the response to microbial infection and has been shown to detect noxious altered-self substances such as apoptotic cells. In this work, using complementary experimental approaches, we identified the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a C1q partner when exposed at the surface of human pathogenic bacteria Streptococcus...
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