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Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator

7 Nov 2013

Abstract excerpt

Streptococcus pneumoniae is not only a commensal of the nasopharyngeal epithelium, but may also cause life-threatening diseases. Immune-electron microscopy studies revealed that the bacterial glycolytic enzyme, phosphoglycerate kinase (PGK), is localised on the pneumococcal surface of both capsulated and non-capsulated strains and colocalises with plasminogen. Since pneumococci may concentrate host plasminogen...

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PMID: 24196407
DOI: 10.1160/th13-05-0421

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