Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signature-tagging of a bacterial isolate demonstrates phenotypic variability of the progeny in vivo in the absence of defined mutations.

Journal of microbiological methods - 1 Dec 2012

Whitby Paul W, VanWagoner Timothy M, Morton Daniel J, Seale Thomas W, Springer Jennifer M, Hempel Randy J, Stull Terrence L

Abstract excerpt

Awareness of the high degree of redundancy that occurs in several nutrient uptake pathways of Haemophilus influenzae led us to attempt to develop a quantitative STM method that could identify both null mutants and mutants with decreased fitness that remain viable in vivo. To accomplish this task we designed a modified STM approach that utilized a set of signature tagged wild-type (STWT) strains (in a single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Genetic Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haemophilus Infections

Share to Haemophilus influenzae

Share to Microbial Viability

Share to Mutation

Share to Otitis Media

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 23085534
DOI: 10.1016/j.mimet.2012.10.005
PMCID: PMC3506178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signature-tagging of a bacterial isolate demonstrates phenotypic variability of the progeny in vivo in the absence of defined mutations.PMID 23085534Read ↗

Genetic requirement for pneumococcal ear infection.Semantic proximity Read ↗

Signature-tagged mutagenesis.Semantic proximity Read ↗

Signature tagged mutagenesis of Haemophilus influenzaeSemantic proximity Read ↗

Nontypeable Haemophilus influenzae Gene Expression Induced In Vivo in a Chinchilla Model of Otitis MediaSemantic proximity Read ↗

Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis mediaSemantic proximity Read ↗

Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media.Semantic proximity Read ↗

Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media.Semantic proximity Read ↗

A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.Semantic proximity Read ↗

A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media.Semantic proximity Read ↗

LuxS Promotes Biofilm Maturation and Persistence of Nontypeable Haemophilus influenzae In Vivo via Modulation of Lipooligosaccharides on the Bacterial SurfaceSemantic proximity Read ↗

Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media.Semantic proximity Read ↗

Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.