Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media.

doi:10.1128/iai.65.11.4431-4435.1997

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Article

Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media.

Infection and immunity - 1 Nov 1997

DeMaria T F, Apicella M A, Nichols W A, Leake E R

Abstract excerpt

Considerable evidence has implicated nontypeable Haemophilus influenzae (NTHi) lipooligosaccharide (LOS) in the pathogenesis of otitis media (OM); however, its exact role has not been conclusively established. Recently, two NTHi LOS-deficient mutants have been created and described. Strain 2019-D...

Topics

Animals
Carbohydrate Epimerases
Chinchilla
Disease Models, Animal
Haemophilus influenzae
Lipopolysaccharides
Mutation
Otitis Media
Virulence

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