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Article

Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media.

Infection and immunity - 1 Nov 1997

DeMaria T F, Apicella M A, Nichols W A, Leake E R

Abstract excerpt

Considerable evidence has implicated nontypeable Haemophilus influenzae (NTHi) lipooligosaccharide (LOS) in the pathogenesis of otitis media (OM); however, its exact role has not been conclusively established. Recently, two NTHi LOS-deficient mutants have been created and described. Strain 2019-DK1, an rfaD gene mutant, expresses a truncated LOS consisting of only three deoxy-D-manno-octulosonic acid residues, a...

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Identifiers

PMID: 9353016
DOI: 10.1128/iai.65.11.4431-4435.1997
PMCID: PMC175637

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