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Article

Screening of influenza mutations using base-specific cleavage and MALDI mass spectrometry.

Clinica chimica acta; international journal of clinical chemistry - 1 May 2013

Gao Xiang, Sugrue Richard J, Tan Boon-Huan, Tang Kai

Abstract excerpt

BACKGROUND: The hemagglutinin (HA) and neuraminidase (NA) genes encode surface glycoproteins of influenza virus. These two proteins are involved in pathogenicity and are the primary targets of the immune system. Mutations in the HA and NA genes can result in antigenic drift in an influenza viral strain. A comparative sequencing method using MALDI MS combined with base-specific cleavage has been applied for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23078853
DOI: 10.1016/j.cca.2012.10.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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