Article
Dominant hemimelia and En-1 on mouse chromosome 1 are not allelic.
Genetical research - 1 Aug 1992
Higgins M, Hill R E, West J D
Abstract excerpt
Previous studies have shown that En-1, a homeobox-containing gene, maps close to or at the Dh locus in the mouse. Since homeobox-containing genes are key genes in the control of development the close proximity of En-1 to the developmentally significant gene Dh raised the possibility that the Dh mutation represented a mutant allele of En-1. A genetic analysis involving En-1, Dh, and other chromosome 1 markers...
Topics
- Animals
- Chromosome Mapping
- Congenital Abnormalities
- Female
- Genes, Dominant
- Genes, Homeobox
- Genetic Linkage
- Genetic Markers
- Limb Deformities, Congenital
- Male
- Mice
- Mice, Mutant Strains