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Article

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.

Human molecular genetics - 15 Aug 2010

Rothenberg Cara, Srinivasan Deepa, Mah Leann, Kaushik Susmita, Peterhoff Corrine M, Ugolino Janet, Fang Shengyun, Cuervo Ana Maria, Nixon Ralph A, Monteiro Mervyn J

Abstract excerpt

Autophagy is the process by which organelles and portions of the cytoplasm are degraded in lysosomes. Several different forms of autophagy are known that are distinguishable chiefly by the mode in which cargo is delivered to the lysosome for degradation. Ubiquilin was recently reported to regulate macroautophagy, the form of autophagy in which cytosolic cargo is packaged in a double-membrane structure or...

Topics

Adaptor Proteins, Signal Transducing
Animals
Autophagy
Autophagy-Related Proteins
Blotting, Western
Brain
Carrier Proteins
Cell Cycle Proteins
Green Fluorescent Proteins
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Huntingtin Protein

Lysosomes

Male

Mice

Mice, Inbred C57BL

Microscopy, Fluorescence

Microscopy, Immunoelectron

Source

Open in PubMed Open full text

Identifiers

PMID: 20529957
DOI: 10.1093/hmg/ddq231
PMCID: PMC2908472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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