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Article

Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy.

The pharmacogenomics journal - 1 Dec 2013

Simon N, Marsot A, Villard E, Choquet S, Khe H-X, Zahr N, Lechat P, Leblond V, Hulot J-S

Abstract excerpt

Human multidrug resistance-related protein 2 (MRP2, encoded by ABCC2) is involved in the transport of anionic drugs such as methotrexate (MTX). We prospectively investigated the influence of four common ABCC2 genetic variants (rs717620, rs2273697, rs8187694 and rs8187710) on MTX pharmacokinetics parameters. MTX concentrations were monitored in 50 patients with lymphoid malignancy (27 males; mean age: 53±17 years)...

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Share to Antimetabolites, Antineoplastic
Share to DNA Primers
Share to Dose-Response Relationship, Drug
Share to Lymphoma
Share to Methotrexate
Share to Multidrug Resistance-Associated Protein 2
Share to Multidrug Resistance-Associated Proteins
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Source

Identifiers

PMID: 23069858
DOI: 10.1038/tpj.2012.37

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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