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Article

Evaluation of MLH1 I219V polymorphism in unrelated South American individuals suspected of having Lynch syndrome.

Anticancer research - 1 Oct 2012

Valentin Mev Dominguez, Da Silva Felipe Carneiro, Santos Erika Maria Monteiro, Da Silva Sabrina Daniela, De Oliveira Ferreira Fabio, Aguiar Junior Samuel, Gomy Israel, Vaccaro Carlos, Redal Maria Ana, Della Valle Adriana, Sarroca Carlos, Rasmussen Lene Juel, Carraro Dirce Maria, Rossi Benedito Mauro

Abstract excerpt

BACKGROUND: Some single-nucleotide polymorphisms are associated with higher risk of colorectal cancer development and are suggested to explain part of the genetic contribution to Lynch syndrome. AIM: To evaluate the mutL homolog 1 (MLH1) I219V polymorphism in 124 unrelated South American individuals suspected of having Lynch syndrome, based on frequency, association with pathogenic MLH1 and mutS homolog 2 (MSH2)...

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Source

Identifiers

PMID: 23060557

Genes

MLH1
MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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