Genetic determinants modulating the pathogenic phenotype of tick-borne orbiviruses.

doi:10.1016/0042-6822(90)90096-a

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Article

Genetic determinants modulating the pathogenic phenotype of tick-borne orbiviruses.

Virology - 1 Feb 1990

Nuttall P A, Moss S R, Carey D, Jones L D, Jacobs S C

Abstract excerpt

Genetic studies have been carried out on orbiviruses in the Great Island (GI) antigenic subgroup of the Kemerovo serogroup (Orbivrus, Reoviridae) to elucidate the functions of the 10 genomic double-stranded RNA segments. Such studies have shown that segment 4 is the major genetic determinant of n...

Topics

Animals
Brain
Genotype
Mice
Phenotype
Reoviridae
Ticks
Virulence
Virus Replication

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