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Genomics‐Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human Pathogenic <i>Burkholderia</i> Species

10 Oct 2012

Abstract excerpt

Biosynthetic secrets unveiled: Targeted promoter exchange in a cryptic biosynthesis gene cluster conserved among certain pathogenic Burkholderia species yielded a highly unstable, structurally unprecedented polyketide, burkholderic acid (1). Labeling experiments, gene knock-outs, and bioinformatics analyses grant first insights into a fascinating polyketide pathway. BurA is an unusual nonribosomal peptide...

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PMID: 23055407
DOI: 10.1002/anie.201205566

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