Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.

PLoS genetics - 1 Mar 2015

Cheng Hui-Min, Chern Yijuang, Chen I-Hui, Liu Chia-Rung, Li Sih-Huei, Chun Seung J, Rigo Frank, Bennett C Frank, Deng Ning, Feng Yanan, Lin Chyuan-Sheng, Yan Yu-Ting, Cohen Stanley N, Cheng Tzu-Hao

Abstract excerpt

Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders. Earlier work has shown that interference w...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Nerve Tissue Proteins

Share to Neurons

Share to Protein Aggregation, Pathological

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 25760041
DOI: 10.1371/journal.pgen.1005043
PMCID: PMC4356588

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25760041-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.PMID 25760041Read ↗

A fully humanized transgenic mouse model of Huntington disease.Semantic proximity Read ↗

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease modelsSemantic proximity Read ↗

Gene therapy in mouse models of huntington disease.Semantic proximity Read ↗

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.Semantic proximity Read ↗

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington's disease.Semantic proximity Read ↗

Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting.Semantic proximity Read ↗

Antisense Oligonucleotide-Mediated Correction of Transcriptional Dysregulation is Correlated with Behavioral Benefits in the YAC128 Mouse Model of Huntington's DiseaseSemantic proximity Read ↗

Selective targeting of mutant <i>huntingtin</i> intron-1 improves rescue provided by antisense oligonucleotidesSemantic proximity Read ↗

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's diseaseSemantic proximity Read ↗

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.Semantic proximity Read ↗

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.Semantic proximity Read ↗

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.