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Article

Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.

PLoS genetics - 1 Mar 2015

Cheng Hui-Min, Chern Yijuang, Chen I-Hui, Liu Chia-Rung, Li Sih-Huei, Chun Seung J, Rigo Frank, Bennett C Frank, Deng Ning, Feng Yanan, Lin Chyuan-Sheng, Yan Yu-Ting, Cohen Stanley N, Cheng Tzu-Hao

Abstract excerpt

Production of protein containing lengthy stretches of polyglutamine encoded by multiple repeats of the trinucleotide CAG is a hallmark of Huntington's disease (HD) and of a variety of other inherited degenerative neurological and neuromuscular disorders. Earlier work has shown that interference with production of the transcription elongation protein SUPT4H results in decreased cellular capacity to transcribe...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25760041
DOI: 10.1371/journal.pgen.1005043
PMCID: PMC4356588

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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