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Article

Resting-state network disruption and APOE genotype in Alzheimer's disease: a lagged functional connectivity study.

PloS one - 1 Jan 2012

Canuet Leonides, Tellado Ivan, Couceiro Veronica, Fraile Carmen, Fernandez-Novoa Lucia, Ishii Ryouhei, Takeda Masatoshi, Cacabelos Ramon

Abstract excerpt

BACKGROUND: The apolipoprotein E epsilon 4 (APOE-4) is associated with a genetic vulnerability to Alzheimer's disease (AD) and with AD-related abnormalities in cortical rhythms. However, it is unclear whether APOE-4 is linked to a specific pattern of intrinsic functional disintegration of the brain after the development of the disease or during its different stages. This study aimed at identifying spatial...

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Source

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Identifiers

PMID: 23050006
DOI: 10.1371/journal.pone.0046289
PMCID: PMC3457973

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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