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Article

Exacerbated mechanical allodynia in rats with depression-like behavior.

Brain research - 20 Mar 2008

Zeng Qing, Wang Shuxing, Lim Grewo, Yang Liling, Mao Ji, Sung Backil, Chang Yang, Lim Jeong-Ae, Guo Gongshe, Mao Jianren

Abstract excerpt

Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the...

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Identifiers

PMID: 18289511
DOI: 10.1016/j.brainres.2008.01.038
PMCID: PMC2386964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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