Article
Mutational screening of the SOCS3 gene promoter in metastatic colorectal cancer patients.
Genetic testing and molecular biomarkers - 1 Dec 2012
Igci Mehri, Cakmak Ecir Ali, Oztuzcu Serdar, Bayram Ali, Arslan Ahmet, Gogebakan Bulent, Igci Yusuf Ziya, Cengiz Beyhan, Ozkara Esma, Camci Celaletdin, Demiryurek A Tuncay
Abstract excerpt
Cytokine-induced expression of suppressors of cytokine signalling (SOCS) molecules is important for the negative feedback control of STAT-dependent cytokine signalling. The aim of this study was to investigate possible association between the promoter region polymorphisms of the SOCS3 gene and metastatic colorectal carcinoma in a Turkish population. The DNA samples obtained from 103 patients and 109 healthy...
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