Article
The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level.
PLoS biology - 1 Oct 2022
Jaric Ivana, Voelkl Bernhard, Clerc Melanie, Schmid Marc W, Novak Janja, Rosso Marianna, Rufener Reto, von Kortzfleisch Vanessa Tabea, Richter S Helene, Buettner Manuela, Bleich André, Amrein Irmgard, Wolfer David P, Touma Chadi, Sunagawa Shinichi, Würbel Hanno
Abstract excerpt
The phenotype of an organism results from its genotype and the influence of the environment throughout development. Even when using animals of the same genotype, independent studies may test animals of different phenotypes, resulting in poor replicability due to genotype-by-environment interactions. Thus, genetically defined strains of mice may respond differently to experimental treatments depending on their...
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