Article
Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds.
Genes, brain, and behavior - 1 Apr 2017
van de Lagemaat L N, Stanford L E, Pettit C M, Strathdee D J, Strathdee K E, Elsegood K A, Fricker D G, Croning M D R, Komiyama N H, Grant S G N
Abstract excerpt
Behavioural analysis of mice carrying engineered mutations is widely used to identify roles of specific genes in components of the mammalian behavioural repertoire. The reproducibility and robustness of phenotypic measures has become a concern that undermines the use of mouse genetic models for translational studies. Contributing factors include low individual study power, non-standardized behavioural testing,...
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