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Article

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.

Nature communications - 5 Nov 2020

Petrova Veselina, Pearson Craig S, Ching Jared, Tribble James R, Solano Andrea G, Yang Yunfei, Love Fiona M, Watt Robert J, Osborne Andrew, Reid Evan, Williams Pete A, Martin Keith R, Geller Herbert M, Eva Richard, Fawcett James W

Abstract excerpt

Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to enhancing regeneration is to increase the axonal supply of growth molecules and organelles. We achieved this by expressing the adaptor molecule Protrudin which is normally found at low levels in non-regenerative neurons. Elevated Protrudin expression enabled...

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Identifiers

PMID: 33154382
DOI: 10.1038/s41467-020-19436-y
PMCID: PMC7645621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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