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Article

Crystal structure of human multiple copies in T-cell lymphoma-1 oncoprotein.

Proteins - 1 Mar 2013

Tempel Wolfram, Dimov Slav, Tong Yufeng, Park Hee-Won, Hong Bum Soo

Abstract excerpt

Overexpression of multiple copies in T-cell lymphoma-1 (MCT-1) oncogene accompanies malignant phenotypic changes in human lymphoma cells. Specific disruption of MCT-1 results in reduced tumorigenesis, suggesting a potential for MCT-1-targeted therapeutic strategy. MCT-1 is known as a cap-binding protein and has a putative RNA-binding motif, the PUA-domain, at its C-terminus. We determined the crystal structure of...

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Identifiers

PMID: 23042581
DOI: 10.1002/prot.24198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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