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Article

α-Synuclein gene duplication impairs reward learning

23 Aug 2010

Abstract excerpt

alpha-Synuclein (SNCA) plays an important role in the regulation of dopaminergic neurotransmission and neurodegeneration in Parkinson disease. We investigated reward and punishment learning in asymptomatic carriers of a rare SNCA gene duplication who were healthy siblings of patients with Parkinson disease. Results revealed that healthy SNCA duplication carriers displayed impaired reward and intact punishment...

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PMID: 20733075
DOI: 10.1073/pnas.1006068107

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