Article
Natural Variation in Human Clocks.
Advances in genetics - 1 Jan 2017
von Schantz Malcolm
Abstract excerpt
Our own species has a diurnal activity pattern and an average circadian period of 24.2h. Exact determination of circadian period requires expensive and intrusive protocols, and investigators are therefore using chronotype questionnaires as a proxy quantitative measure. Both measures show a normal distribution suggestive of a polygenic trait. The genetic components of the 24-h feedback loop that generates...
Topics
- CLOCK Proteins
- Circadian Clocks
- Circadian Rhythm
- Genome-Wide Association Study
- Humans
- Mutation
- Phenotype
- Sleep Wake Disorders