Association between human prothrombin variant (T165M) and kidney stone disease.

doi:10.1371/journal.pone.0045533

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Article

Association between human prothrombin variant (T165M) and kidney stone disease.

PloS one - 1 Jan 2012

Rungroj Nanyawan, Sudtachat Nirinya, Nettuwakul Choochai, Sawasdee Nunghathai, Praditsap Oranud, Jungtrakoon Prapaporn, Sritippayawan Suchai, Chuawattana Duangporn, Borvornpadungkitti Sombat, Predanon Chagkrapan, Susaengrat Wattanachai, Yenchitsomanus Pa-Thai

Abstract excerpt

We previously reported the association between prothrombin (F2), encoding a stone inhibitor protein - urinary prothrombin fragment 1 (UPTF1), and the risk of kidney stone disease in Northeastern Thai patients. To identify specific F2 variation responsible for the kidney stone risk, we conducted sequencing analysis of this gene in a group of the patients with kidney stone disease. Five intronic SNPs (rs2070850,...

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PMID: 23029076
DOI: 10.1371/journal.pone.0045533
PMCID: PMC3446884

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