Article
The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors.
PloS one - 1 Jan 2012
Benisch Peggy, Schilling Tatjana, Klein-Hitpass Ludger, Frey Sönke P, Seefried Lothar, Raaijmakers Nadja, Krug Melanie, Regensburger Martina, Zeck Sabine, Schinke Thorsten, Amling Michael, Ebert Regina, Jakob Franz
Abstract excerpt
Primary osteoporosis is an age-related disease characterized by an imbalance in bone homeostasis. While the resorptive aspect of the disease has been studied intensely, less is known about the anabolic part of the syndrome or presumptive deficiencies in bone regeneration. Multipotent mesenchymal stem cells (MSC) are the primary source of osteogenic regeneration. In the present study we aimed to unravel whether...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.