Epicardium derived cells (EPDCs) in development, cardiac disease and repair of ischemia

doi:10.1111/j.1582-4934.2010.01077.x

Article

Epicardium derived cells (EPDCs) in development, cardiac disease and repair of ischemia

1 Apr 2010

Abstract excerpt

Reactivation of endogenous epicardium after ischemia The proepicardial-derived epicardium covers the myocardium and after a process of epithelial-mesenchymal transition (EMT) forms epicardium-derived cells (EPDCs). These cells migrate into the myocardium and show an essential role in the induction of the ventricular compact myocardium and the differentiation of the Purkinje fibres. EPDCs are furthermore the...

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