Article
Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons.
PloS one - 1 Jan 2012
Busceti Carla Letizia, Bucci Domenico, Molinaro Gemma, Di Pietro Paola, Zangrandi Luca, Gradini Roberto, Moratalla Rosario, Battaglia Giuseppe, Bruno Valeria, Nicoletti Ferdinando, Fornai Francesco
Abstract excerpt
We examined the role of endogenous dopamine (DA) in regulating the number of intrinsic tyrosine hydroxylase-positive (TH(+)) striatal neurons using mice at postnatal day (PND) 4 to 8, a period that corresponds to the developmental peak in the number of these neurons. We adopted the strategy of depleting endogenous DA by a 2-day treatment with α-methyl-p-tyrosine (αMpT, 150 mg/kg, i.p.). This treatment markedly...
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