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Article

Nicotinamide reduces dopamine in postnatal hypothalamus and causes dopamine-deficient phenotype.

Neuroscience letters - 18 Sept 2009

Lee Jae-Yong, Ahn Kyungsook, Jang Bong Geom, Park Seong-Hoon, Kang Hong-Jun, Heo Jee-In, Ko Yoon-Jung, Won Moo-Ho, Tae-Cheon Kang, Jo Sangmee Ahn, Kim Min-Ju

Abstract excerpt

Dopamine is an important neurotransmitter in the human central nervous system and also plays a key role in the development of postnatal brains. We previously reported that nicotinamide, a SIRT1 inhibitor, regulates tyrosine hydroxylase (TH) expression in vitro. To investigate the effect of nicotinamide-mediated TH regulation in vivo, nicotinamide was chronically injected into neonatal mice. Interestingly,...

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Identifiers

PMID: 19539713
DOI: 10.1016/j.neulet.2009.06.005

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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