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Article

The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence.

PloS one - 1 Jan 2012

Oliver Jason D, Kaye Sarah J, Tuckwell Danny, Johns Anna E, Macdonald Darel A, Livermore Joanne, Warn Peter A, Birch Mike, Bromley Michael J

Abstract excerpt

Dihydroxyacid dehydratase (DHAD) is a key enzyme in the branched-chain amino acid biosynthetic pathway that exists in a variety of organisms, including fungi, plants and bacteria, but not humans. In this study we identified four putative DHAD genes from the filamentous fungus Aspergillus fumigatus by homology to Saccharomyces cerevisiae ILV3. Two of these genes, AFUA_2G14210 and AFUA_1G03550, initially designated...

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Identifiers

PMID: 23028460
DOI: 10.1371/journal.pone.0043559
PMCID: PMC3445565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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