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Article

Tissue-specific functional networks for prioritizing phenotype and disease genes.

PLoS computational biology - 1 Jan 2012

Guan Yuanfang, Gorenshteyn Dmitriy, Burmeister Margit, Wong Aaron K, Schimenti John C, Handel Mary Ann, Bult Carol J, Hibbs Matthew A, Troyanskaya Olga G

Abstract excerpt

Integrated analyses of functional genomics data have enormous potential for identifying phenotype-associated genes. Tissue-specificity is an important aspect of many genetic diseases, reflecting the potentially different roles of proteins and pathways in diverse cell lineages. Accounting for tissue specificity in global integration of functional genomics data is challenging, as "functionality" and "functional...

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Identifiers

PMID: 23028291
DOI: 10.1371/journal.pcbi.1002694
PMCID: PMC3459891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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