In vivo egress of an alphaherpesvirus from axons.

doi:10.1128/jvi.76.16.8310-8317.2002

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Article

In vivo egress of an alphaherpesvirus from axons.

Journal of virology - 1 Aug 2002

Tomishima Mark J, Enquist Lynn W

Abstract excerpt

Many alphaherpesviruses establish a latent infection in the peripheral nervous systems of their hosts. This life cycle requires the virus to move long distances in axons toward the neuron's cell body during infection and away from the cell body during reactivation. While the events underlying entry of the virion into neurons during infection are understood in principle, no such consensus exists regarding viral...

Topics

Alphaherpesvirinae
Animals
Axonal Transport
Axons
Gene Deletion
Genes, Viral
Herpesviridae Infections
Herpesvirus 1, Suid
Male
Models, Neurological
Mutation
Optic Nerve
Peripheral Nervous System Diseases
Rats
Rats, Sprague-Dawley
Retinal Diseases
Viral Envelope Proteins
Virus Latency

Source

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Identifiers

PMID: 12134036
DOI: 10.1128/jvi.76.16.8310-8317.2002
PMCID: PMC155153

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