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Miliary brain metastases in 2 cases with advanced non-small cell lung cancer harboring EGFR mutation during gefitinib treatment.

Respiratory investigation - 1 Sept 2012

Mochizuki Sayaka, Nishimura Naoki, Inoue Akira, Murakami Koji, Nukiwa Toshihiro, Chohnabayashi Naohiko

Abstract excerpt

Here we report 2 cases of non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor (EGFR) gene mutation that developed miliary brain metastases characterized by dementia and disorientation during gefitinib therapy. One patient's therapy was switched from gefitinib to chemotherapy followed by whole brain radiotherapy (WBRT), which resulted in disease progression with coma. Gefitinib...

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Identifiers

PMID: 23021771
DOI: 10.1016/j.resinv.2012.06.002

Genes

EGFR

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