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Article

Promising Effects of Afatinib on Leptomeningeal Carcinomatosis Derived from Erlotinib-resistant Lung Adenocarcinoma.

Internal medicine (Tokyo, Japan) - 1 Jan 2016

Sekine Akimasa, Kato Terufumi, Iwasawa Tae, Baba Tomohisa, Suido Akihiro, Sakuranaka Haruyasu, Futaki Masaaki, Ogura Takashi

Abstract excerpt

We herein report a case of a 67-year-old woman previously treated with erlotinib for adenocarcinoma with an epidermal growth factor receptor (EGFR) mutation in exon 19, which rapidly developed to progressive symptomatic leptomeningeal carcinomatosis. The primary tumor and lung metastases also worsened and the performance status (PS) score declined to 3. With a re-biopsy from the pulmonary metastases, the T790M...

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Source

Identifiers

PMID: 27580550
DOI: 10.2169/internalmedicine.55.6102

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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