Article
Erlotinib accumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2011
Weber Britta, Winterdahl Michael, Memon Ashfaque, Sorensen Boe S, Keiding Susanne, Sorensen Leif, Nexo Ebba, Meldgaard Peter
Abstract excerpt
INTRODUCTION: Drugs directed toward the epidermal growth factor receptor (EGFR), such as erlotinib (Tarceva®) and gefitinib (Iressa®), are used for the treatment of patients with advanced non-small cell lung cancer (NSCLC), including patients with brain metastases. However, whether erlotinib actually enters into brain metastases has not been adequately elucidated. In this study, we investigated the accumulation...
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