Article
Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2009
Katayama Tatsuya, Shimizu Junichi, Suda Kenichi, Onozato Ryoichi, Fukui Takayuki, Ito Simon, Hatooka Shunzo, Sueda Taijiro, Hida Toyoaki, Yatabe Yasushi, Mitsudomi Tetsuya
Abstract excerpt
INTRODUCTION: The efficacy of high-dose (1250 mg/d) gefitinib for the treatment of leptomeningeal metastasis in a patient with lung cancer harboring a mutation in the epidermal growth factor receptor (EGFR) gene was previously reported. We speculate that erlotinib, instead of high dose of gefitinib, may be also effective for the treatment of central nervous system (CNS) lesions, as trough serum concentration of...
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