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Cerebral infarction after treatment with dabrafenib plus trametinib for BRAF-V600E-positive non-small cell lung cancer: A case report.

Thoracic cancer - 1 May 2023

Taniguchi Yoshihiko, Tamiya Akihiro, Yanagisawa Atsushi, Shimaya Minako, Kawakami Mayu, Inagaki Yuji, Saijo Nobuhiko, Matsuda Yoshinobu, Okishio Kyoichi

Abstract excerpt

Dabrafenib plus trametinib is the standard treatment for BRAF V600E-mutated non-small cell lung cancer. No treatment-related cerebral infarction (CI) has been reported in previous clinical trials. Here, we described a 61-year-old Japanese man with BRAF V600E-mutated lung adenocarcinoma treated with dabrafenib plus trametinib as a third-line treatment. On the 10th day of dabrafenib plus trametinib treatment, the...

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Identifiers

PMID: 36935386
DOI: 10.1111/1759-7714.14852
PMCID: PMC10151131

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