Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sedlin controls the ER export of procollagen by regulating the Sar1 cycle.

Science (New York, N.Y.) - 28 Sept 2012

Venditti Rossella, Scanu Tiziana, Santoro Michele, Di Tullio Giuseppe, Spaar Alexander, Gaibisso Renato, Beznoussenko Galina V, Mironov Alexander A, Mironov Alexander, Zelante Leopoldo, Piemontese Maria Rosaria, Notarangelo Angelo, Malhotra Vivek, Vertel Barbara M, Wilson Cathal, De Matteis Maria Antonietta

Abstract excerpt

Newly synthesized proteins exit the endoplasmic reticulum (ER) via coat protein complex II (COPII) vesicles. Procollagen (PC), however, forms prefibrils that are too large to fit into typical COPII vesicles; PC thus needs large transport carriers, which we term megacarriers. TANGO1 assists PC pac...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Chondrogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COP-Coated Vesicles

Share to Endoplasmic Reticulum

Share to Golgi Apparatus

Share to Monomeric GTP-Binding Proteins

Share to Osteochondrodysplasias

Share to Procollagen

Source

Open in PubMed Open full text

Identifiers

PMID: 23019651
DOI: 10.1126/science.1224947
PMCID: PMC3471527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23019651-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sedlin controls the ER export of procollagen by regulating the Sar1 cycle.PMID 23019651Read ↗

Defining the cellular and molecular basis of Spondyloepiphyseal dysplasia tardaSemantic proximity Read ↗

Role of sedlin, a TRAPP complex subunit, in membrane trafficking and in the pathogenesis of Spondyleopyphiseal Dysplasia TardaSemantic proximity Read ↗

A general role for MIA3/TANGO1 in secretory pathway organization and functionSemantic proximity Read ↗

Role of trafficking protein particle complex 2 in medaka developmentSemantic proximity Read ↗

Role of trafficking protein particle complex 2 in medaka development.Semantic proximity Read ↗

Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion.Semantic proximity Read ↗

Functions of Gle1 are governed by two distinct modes of self-associationSemantic proximity Read ↗

Functions of Gle1 are governed by two distinct modes of self-associationSemantic proximity Read ↗

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.Semantic proximity Read ↗

Biallelic <i>TANGO1</i> mutations cause a novel syndromal disease due to hampered cellular collagen secretionSemantic proximity Read ↗

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulumSemantic proximity Read ↗

ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.