Article
Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.
Schizophrenia research - 1 Nov 2012
Mattheisen Manuel, Mühleisen Thomas W, Strohmaier Jana, Treutlein Jens, Nenadic Igor, Alblas Margrieta, Meier Sandra, Degenhardt Franziska, Herms Stefan, Hoffmann Per, Witt Stephanie H, Giegling Ina, Sauer Heinrich, Schulze Thomas G, Rujescu Dan, Nöthen Markus M, Rietschel Marcella, Cichon Sven
Abstract excerpt
Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence...
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