Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STON2 variations are involved in synaptic dysfunction and schizophrenia-like behaviors by regulating Syt1 trafficking.

Science bulletin - 30 May 2024

Ma Yuanlin, Gao Kai, Sun Xiaoxuan, Wang Jinxin, Yang Yang, Wu Jianying, Chai Anping, Yao Li, Liu Nan, Yu Hao, Su Yi, Lu Tianlan, Wang Lifang, Yue Weihua, Zhang Xiaohui, Xu Lin, Zhang Dai, Li Jun

Abstract excerpt

Synaptic dysfunction is a core component of the pathophysiology of schizophrenia. However, the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully understood. The Stonin 2 (STON2) gene encodes a major adaptor for clathrin-mediated endocytosis (CME) of synaptic vesicles. In this study, we showed that the C-C (307Pro-851Ala) haplotype of STON2 increases the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Haloperidol

Share to Synapses

Share to Synaptic Transmission

Share to Synaptic Vesicles

Share to Synaptotagmin I

Source

Identifiers

PMID: 38402028
DOI: 10.1016/j.scib.2024.02.013

Genes

STON2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STON2 variations are involved in synaptic dysfunction and schizophrenia-like behaviors by regulating Syt1 trafficking.PMID 38402028Read ↗

Positive association of the human STON2 gene with schizophrenia.Semantic proximity Read ↗

Identification and functional characterization of rare SHANK2 variants in schizophrenia.Semantic proximity Read ↗

Multi-level computational analysis identifies schizophrenia missense SNPs with implications for synaptic function, neuroimmune dysfunction, and antipsychotic response.Semantic proximity Read ↗

Schizophrenia-linked protein tSNARE1 regulates endolysosomal trafficking in cortical neuronsSemantic proximity Read ↗

TSNARE1 polymorphisms are associated with schizophrenia susceptibility in Han Chinese.Semantic proximity Read ↗

Identification of SHANK2 Pathogenic Variants in a Chinese Uygur Population with Schizophrenia.Semantic proximity Read ↗

Disease-causing mutations in Synaptotagmin can act via dominant-negative, gain-of-function or haploinsufficient mechanismsSemantic proximity Read ↗

Adaptive functions correlate with evoked neurotransmitter release in SYT1-associated neurodevelopmental disorderSemantic proximity Read ↗

Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder.Semantic proximity Read ↗

Endosomal trafficking in schizophrenia.Semantic proximity Read ↗

The schizophrenia risk gene product miR-137 alters presynaptic plasticity.Semantic proximity Read ↗

Investigation of SHANK3 in schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.