Article
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Alzheimer's disease.
The Journal of clinical endocrinology and metabolism - 1 Dec 2012
Duron Emmanuelle, Funalot Benoît, Brunel Nadège, Coste Joel, Quinquis Laurent, Viollet Cécile, Belmin Joel, Jouanny Pierre, Pasquier Florence, Treluyer Jean-Marc, Epelbaum Jacques, le Bouc Yves, Hanon Olivier
Abstract excerpt
CONTEXT: Few large studies have been conducted to assess the relationship between circulating IGF and late-life cognition. OBJECTIVE: The aim of the study was to assess the relationship between IGF-I and IGF binding protein-3 (IGFBP-3) serum levels and cognitive impairment, including Alzheimer's disease (AD). METHODS: In this multicentric cross-sectional study, 694 elderly subjects (218 men, 476 women; 78.6 ± 6.7...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoproteins E
- Cognition
- Cross-Sectional Studies
- Female
- Genotype
- Humans
- Insulin-Like Growth Factor Binding Protein 3