A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis.

doi:10.1073/pnas.87.3.896

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Article

A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Rinchik E M, Carpenter D A, Selby P B

Abstract excerpt

A refined functional map of a 6- to 11-centimorgan region surrounding the albino (c) locus in mouse chromosome 7 is being generated by N-ethyl-N-nitrosourea (EtNU) "saturation" mutagenesis of stem-cell spermatogonia. In the first phase of an experiment that will eventually test at least 3000 gametes, we screened 972 mutagenized gametes for the induction of both lethal and visible mutations with a two-cross...

Topics

Albinism
Alleles
Animals
Chromosome Deletion
Chromosome Mapping
Crosses, Genetic
Ethylnitrosourea
Female
Genes, Lethal
Genes, Recessive
Genetic Carrier Screening

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Complementation Test

Male

Mice

Mice, Inbred BALB C

Mice, Inbred C3H

Mutation

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 2300582
DOI: 10.1073/pnas.87.3.896
PMCID: PMC53375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2300582-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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