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Article

Reduced expression of STOP/MAP6 in mice leads to cognitive deficits.

Schizophrenia bulletin - 1 Sept 2013

Volle Julien, Brocard Jacques, Saoud Mohamed, Gory-Faure Sylvie, Brunelin Jérôme, Andrieux Annie, Suaud-Chagny Marie-Françoise

Abstract excerpt

BACKGROUND: STOP/MAP6 null (KO) mice recapitulate behavioral abnormalities related to positive and negative symptoms and cognitive deficits of schizophrenia. Here, we investigated whether decreased expression of STOP/MAP6 proteins in heterozygous mice (only one allele expressed) would result in abnormal behavior related to those displayed by STOP null mice. METHODS: Using a comprehensive test battery, we...

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Source

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Identifiers

PMID: 23002183
DOI: 10.1093/schbul/sbs113
PMCID: PMC3756782

Genes

MAP6

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