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Article

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.

Nature medicine - 1 Oct 2012

Skokowa Julia, Klimiankou Maxim, Klimenkova Olga, Lan Dan, Gupta Kshama, Hussein Kais, Carrizosa Esteban, Kusnetsova Inna, Li Zhixiong, Sustmann Claudio, Ganser Arnold, Zeidler Cornelia, Kreipe Hans-Heinrich, Burkhardt Janis, Grosschedl Rudolf, Welte Karl

Abstract excerpt

We found that hematopoietic cell-specific Lyn substrate 1 (HCLS1 or HS1) is highly expressed in human myeloid cells and that stimulation with granulocyte colony-stimulating factor (G-CSF) leads to HCLS1 phosphorylation. HCLS1 binds the transcription factor lymphoid-enhancer binding factor 1 (LEF-1), transporting LEF-1 into the nucleus upon G-CSF stimulation and inducing LEF-1 autoregulation. In patients with...

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Source

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Identifiers

PMID: 23001182
DOI: 10.1038/nm.2958
PMCID: PMC3941918

Genes

HCLS1
HAX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.PMID 23001182Read ↗

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