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Article

Kostmann's Disease and HCLS1-Associated Protein X-1 (HAX1).

Journal of clinical immunology - 1 Feb 2017

Klein Christoph

Abstract excerpt

Severe congenital neutropenia (SCN), originally described by the Swedish pediatrician Rolf Kostmann, constitutes a heterogeneous disorder associated with a dramatic decrease of peripheral neutrophil granulocytes. Patients suffer from life-threatening bacterial infections unless treated by recombinant human granulocyte colony stimulating factor (G-CSF) or allogeneic hematopoietic stem cells. This review is focused...

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Source

Identifiers

PMID: 27943080
DOI: 10.1007/s10875-016-0358-2

Genes

HAX1
HCLS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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