Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.

Fertility and sterility - 1 Jan 2013

Nomikos Michail, Yu Yuansong, Elgmati Khalil, Theodoridou Maria, Campbell Karen, Vassilakopoulou Vyronia, Zikos Christos, Livaniou Evangelia, Amso Nazar, Nounesis George, Swann Karl, Lai F Anthony

Abstract excerpt

OBJECTIVE: To determine the effect of infertility-linked sperm phospholipase Cζ (PLCζ) mutations on their ability to trigger oocyte Ca(2+) oscillations and development, and also to evaluate the potential therapeutic utility of wild-type, recombinant PLCζ protein for rescuing failed oocyte activation and embryo development. DESIGN: Test of a novel therapeutic approach to male factor infertility. SETTING:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Development
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Microinjections

Share to Models, Animal

Share to Oocytes

Share to Phosphoinositide Phospholipase C

Share to Sperm-Ovum Interactions

Source

Open in PubMed Open full text

Identifiers

PMID: 22999959
DOI: 10.1016/j.fertnstert.2012.08.035
PMCID: PMC3540263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.PMID 22999959Read ↗

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.Semantic proximity Read ↗

Oocyte activation, phospholipase C zeta and human infertility.Semantic proximity Read ↗

Phospholipase C Zeta in Human Spermatozoa: A Systematic Review on Current Development and Clinical ApplicationSemantic proximity Read ↗

The mammalian sperm factor phospholipase C zeta is critical for early embryo division and pregnancy in humans and miceSemantic proximity Read ↗

Oocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technologySemantic proximity Read ↗

Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An UpdateSemantic proximity Read ↗

A Novel PLCζ Mutation Linked to Male Factor Infertility Induces a Gain-of-Function Effect on Ca2+ Oscillations in EggsSemantic proximity Read ↗

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζSemantic proximity Read ↗

The sperm phospholipase C-ζ and Ca2+ signalling at fertilization in mammalsSemantic proximity Read ↗

SPERM FACTORS AND EGG ACTIVATION: Fertilization failure after human ICSI and the clinical potential of PLCZ1Semantic proximity Read ↗

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.Semantic proximity Read ↗

Diagnosis and Treatment of Male Infertility-Related Fertilization FailureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.