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Article

Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2014

Chakraborty Papia, William Buaas F, Sharma Manju, Smith Benjamin E, Greenlee Anne R, Eacker Stephen M, Braun Robert E

Abstract excerpt

Sertoli cell tight junctions (SCTJs) of the seminiferous epithelium create a specialized microenvironment in the testis to aid differentiation of spermatocytes and spermatids from spermatogonial stem cells. SCTJs must be chronically broken and rebuilt with high fidelity to allow the transmigration of preleptotene spermatocytes from the basal to adluminal epithelial compartment. Impairment of androgen signaling in...

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Identifiers

PMID: 24825397
DOI: 10.1210/me.2013-1134
PMCID: PMC4075161

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