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Article

Polygenic threshold model with sex dimorphism in adolescent idiopathic scoliosis: the Carter effect.

The Journal of bone and joint surgery. American volume - 15 Aug 2012

Kruse Lisa M, Buchan Jillian G, Gurnett Christina A, Dobbs Matthew B

Abstract excerpt

BACKGROUND: Adolescent idiopathic scoliosis occurs between two and ten times more frequently in females than in males. The exact cause of this sex discrepancy is unknown, but it may represent a difference in susceptibility to the deformity. If this difference is attributable to genetic factors, t...

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Identifiers

PMID: 22992817
DOI: 10.2106/JBJS.K.01450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22992817-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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