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Article

Polygenic threshold model with sex dimorphism in clubfoot inheritance: the Carter effect.

The Journal of bone and joint surgery. American volume - 1 Dec 2008

Kruse Lisa M, Dobbs Matthew B, Gurnett Christina A

Abstract excerpt

BACKGROUND: Idiopathic clubfoot is approximately twice as common in males than in females. The reason for this discrepancy is unclear but may represent an inherent difference in the susceptibility to the deformity. If this difference is due to genetic factors it is predicted that in order to inherit clubfoot, females need to have a greater number of susceptibility genes than males. Females would also be more...

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Identifiers

PMID: 19047715
DOI: 10.2106/JBJS.G.01346
PMCID: PMC2663333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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