Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.

Cardiovascular research - 1 Jan 2013

Ruggiero Alessandra, Chen Suet Nee, Lombardi Raffaella, Rodriguez Gabriela, Marian Ali J

Abstract excerpt

AIMS: The role of calcineurin protein phosphatase 2B (PP2B) in the pathogenesis of human hypertrophic cardiomyopathy (HCM) remains unsettled. We determined potential involvement of calcineurin in the pathogenesis of HCM caused by mutations in myozenin 2 (MYOZ2), an inhibitor of calcineurin. METHO...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to Calcium-Binding Proteins
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Fibrosis

Share to JNK Mitogen-Activated Protein Kinases

Share to Muscle Proteins

Share to NFATC Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22987565
DOI: 10.1093/cvr/cvs294
PMCID: PMC3527764

Genes

MYOZ2
RCAN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22987565-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.PMID 22987565Read ↗

Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy.Semantic proximity Read ↗

Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and FunctionSemantic proximity Read ↗

A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice.Semantic proximity Read ↗

Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac HypertrophySemantic proximity Read ↗

MEF2 Activates a Genetic Program Promoting Chamber Dilation and Contractile Dysfunction in Calcineurin-Induced Heart FailureSemantic proximity Read ↗

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.Semantic proximity Read ↗

The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity.Semantic proximity Read ↗

Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis.Semantic proximity Read ↗

Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosisSemantic proximity Read ↗

Mono- and bi-allelic protein truncating variants in alpha-actinin 2 cause cardiomyopathy through distinct mechanismsSemantic proximity Read ↗

Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy.Semantic proximity Read ↗

Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.