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O6-Methylguanine-DNA methyltransferase is a novel negative effector of invasion in glioblastoma multiforme.

Molecular cancer therapeutics - 1 Nov 2012

Chahal Manik, Abdulkarim Bassam, Xu Yaoxian, Guiot Marie-Christine, Easaw Jacob C, Stifani Nicolas, Sabri Siham

Abstract excerpt

The dismal prognosis of glioblastoma multiforme (GBM) is mostly due to the high propensity of GBM tumor cells to invade. We reported an inverse relationship between GBM angiogenicity and expression of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT), which has been extensively characterized for its role in resistance to alkylating agents used in GBM treatment. In the present study, given the...

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Cell Shape
Focal Adhesion Protein-Tyrosine Kinases
Gene Knockdown Techniques
Glioblastoma
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

O(6)-Methylguanine-DNA Methyltransferase

RNA, Small Interfering

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Identifiers

PMID: 22986464
DOI: 10.1158/1535-7163.MCT-11-0977

Genes

MGMT
SPARC

Variants

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