Article
Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort.
Heart rhythm - 1 Jun 2007
Koopmann Tamara T, Beekman Leander, Alders Marielle, Meregalli Paola G, Mannens Marcel M A M, Moorman Antoon F M, Wilde Arthur A M, Bezzina Connie R
Abstract excerpt
BACKGROUND: The Brugada syndrome is an inherited cardiac electrical disorder associated with a high incidence of life-threatening arrhythmias. Screening for mutations in the cardiac Na+ channel-encoding gene SCN5A uncovers a mutation in approximately 20% of Brugada syndrome cases. Genetic heterog...
Topics
- Brugada Syndrome
- Case-Control Studies
- Gene Deletion
- Humans
- Muscle Proteins
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel
- Netherlands
- Polymorphism, Genetic
- Risk Factors
- Sodium Channels