Article
[Studying of molecular mechanisms of rubella virus attenuation evidence from Russian strain C-77].
Molekuliarnaia genetika, mikrobiologiia i virusologiia - 1 Jan 2012
Dmitriev G V, Borisova T K, Faĭzuloev E B, Zabiiaka Iu I, Desiatskova R G, Zverev V V
Abstract excerpt
Live attenuated rubella vaccine is used for vaccination. Temperature-sensitive (ts) phenotype was proved for almost all rubella vaccine strains, and the acquisition of the ts phenotype during cold adaptation was strongly correlated with the attenuation of the wild-type viruses. Nevertheless, the molecular mechanisms of the attenuation have been insufficiently understood for rubella virus. Study ofthese...
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